Mgll Gene Summary [Mouse]
This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | Mgll |
| Official Name | monoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042] |
| Ensembl ID | ENSMUSG00000033174 |
| Bio databases IDs | |
| Aliases | monoglyceride lipase |
| Synonyms | FLJ22330, HU-K5, MAGL, MGL, mLipase, MONOACYLGLYCEROL LIPASE, Monoglyceride Lipase, MONOGLYCEROL LIPASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgll often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- lysophospholipase
- alpha/beta hydrolases
- Serine aminopeptidase, S33
- Alpha/beta hydrolase family
- acylglycerol lipase
- protein homodimerization
- enzyme
- hydrolase
- protein binding
Pathways
Biological processes and signaling networks where the Mgll gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- plasma cell myeloma
- Waldenström macroglobulinemia
- COVID-19
- type M3 acute myeloid leukemia
- liver cancer
- epithelial cancer
- Crohn disease
- septic shock
role in cell
- expression in
- phosphorylation in
- autophagy in
- invasion by
- proliferation
- colony formation
- accumulation in
- activation in
- migration
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- presynaptic regions
- cellular membrane
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- growth cone
- dendrite initial segments
- synapse
- perikaryon
- axons
- axon terminals
- mossy fiber boutons
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgll gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- acylglycerol catabolic process
- monoacylglycerol catabolic process
- lipid metabolic process
- regulation of endocannabinoid signaling pathway
- regulation of inflammatory response
- triglyceride catabolic process
- fatty acid biosynthetic process
- arachidonic acid metabolic process
- regulation of signal transduction
- regulation of sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- acylglycerol lipase activity
- protein binding
- protein homodimerization activity