Gabrb3 Gene Summary [Mouse]
Enables GABA-A receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in several processes, including chloride transmembrane transport; inner ear development; and nervous system development. Acts upstream of or within several processes, including cellular response to zinc ion; circadian sleep/wake cycle, REM sleep; and learning or memory. Part of GABA-A receptor complex. Is active in GABA-ergic synapse and cell surface. Is expressed in several structures, including central nervous system; eye; jaw; and olfactory epithelium. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; childhood absence epilepsy; developmental and epileptic encephalopathy 43; and heroin dependence. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrb3 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 [Source:MGI Symbol;Acc:MGI:95621] |
| Ensembl ID | ENSMUSG00000033676 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 |
| Synonyms | A230092K12Rik, beta3, beta3 subunit of GABAA receptors, Cp1, DEE43, ECA5, EIEE43, GABA A receptor B3, Gaba A receptor subunit β 3, Gaba A receptor β-3, GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3, GABRB3, γ-aminobutyric acid type A receptor subunit β 3, gamma-aminobutyric acid type A receptor subunit beta 3, γ-aminobutyric acid type A receptor subunit beta3, γ-aminobutyric acid type A receptor subunit β 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabrb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- extracellular domain
- intracellular loop
- transmembrane helix kinks
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- identical protein binding
- ion channel
- anion channel
- LGIC_ECD
- neurotransmitter receptor
- binding protein
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- transmembrane domain
- ligand-gated ion channel
- intracellular domain
Pathways
Biological processes and signaling networks where the Gabrb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- dopamine
- oxygen
- chloride
- carbon dioxide
- GABA-A receptor
disease
- cancer
- gastrointestinal stromal tumor
- disorder of coronary artery
- chronic kidney disease
- end stage renal disease
- weight gain
- HIV infection
- brain ischemia
- Pneumocystosis jiroveci pneumonia
- COVID-19
phenotypes
- abnormal CNS synaptic transmission
- abnormal GABA-mediated receptor currents
- abnormal action potential
- abnormal auditory brainstem response waveform shape
- abnormal behavior
- abnormal cerebellum vermis lobule II morphology
- abnormal cerebellum vermis lobule III morphology
- abnormal cerebellum vermis lobule IV morphology
- abnormal cerebellum vermis lobule V morphology
- abnormal cerebellum vermis lobule VI morphology
- abnormal cerebellum vermis lobule VII morphology
- abnormal cerebellum vermis lobule morphology
- abnormal cochlea morphology
- abnormal cochlear IHC afferent innervation pattern
- abnormal cochlear OHC efferent innervation pattern
- abnormal cochlear nerve morphology
- abnormal dentate gyrus neuron dendrite morphology
- abnormal distortion product otoacoustic emission
- abnormal excitatory postsynaptic currents
- abnormal hippocampus neuron morphology
- abnormal inhibitory postsynaptic potential
- abnormal motor capabilities/coordination/movement
- abnormal nest building behavior
- abnormal parental behavior
- abnormal reflex
- abnormal response to novel object
- abnormal response to social novelty
- abnormal social/conspecific interaction
- altered righting response
- circling
- cleft palate
- cochlear ganglion degeneration
- cochlear ganglion hypoplasia
- cochlear inner hair cell degeneration
- cochlear outer hair cell degeneration
- decreased body size
- decreased vertical activity
- enhanced contextual conditioning behavior
- hyperactivity
- hyperresponsive
- impaired behavioral response to xenobiotic
- impaired coordination
- impaired swimming
- increased excitatory postsynaptic current amplitude
- increased or absent threshold for auditory brainstem response
- increased stereotypic behavior
- increased susceptibility to pharmacologically induced seizures
- lethality at weaning complete penetrance
- limb grasping
- neonatal lethality incomplete penetrance
- no abnormal phenotype detected
- perinatal lethality incomplete penetrance
- premature death
- seizures
- sensorineural hearing loss
- small cochlear ganglion
- small vestibular ganglion
- tremors
- type IV spiral ligament fibrocyte degeneration
- vestibular ganglion hypoplasia
role in cell
- density
- development
- degeneration
- assembly
- sprouting angiogenesis by
- response by
- innervation
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- sperm head
- dendritic spines
- synaptosomes
- synapse
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabrb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- cellular response to histamine
- signal transduction
- palate development
- synaptic transmission
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- cytoplasmic vesicle membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- GABA-A receptor activity
- neurotransmitter receptor activity
- chloride channel activity
- GABA-gated chloride ion channel activity