Gabrb3 Gene Summary [Rat]
Enables AP-2 adaptor complex binding activity; GABA-A receptor activity; and GABA-gated chloride ion channel activity. Involved in GABAergic synaptic transmission and response to auditory stimulus. Located in several cellular components, including inhibitory synapse; sperm head; and terminal bouton. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and status epilepticus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; childhood absence epilepsy; developmental and epileptic encephalopathy 43; and heroin dependence. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrb3 |
| Official Name | gamma-aminobutyric acid type A receptor beta 3 subunit [Source:RGD Symbol;Acc:2651] |
| Ensembl ID | ENSRNOG00000060599 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor beta 3 subunit |
| Synonyms | A230092K12Rik, beta3, beta3 subunit of GABAA receptors, Cp1, DEE43, ECA5, EIEE43, GABA A receptor B3, Gaba A receptor subunit β 3, Gaba A receptor β-3, GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3, GABRB3, γ-aminobutyric acid type A receptor subunit β 3, gamma-aminobutyric acid type A receptor subunit beta 3, γ-aminobutyric acid type A receptor subunit beta3, γ-aminobutyric acid type A receptor subunit β 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabrb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- extracellular domain
- intracellular loop
- transmembrane helix kinks
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- identical protein binding
- ion channel
- anion channel
- LGIC_ECD
- neurotransmitter receptor
- binding protein
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- transmembrane domain
- ligand-gated ion channel
- intracellular domain
Pathways
Biological processes and signaling networks where the Gabrb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- gastrointestinal stromal tumor
- disorder of coronary artery
- chronic kidney disease
- end stage renal disease
- weight gain
- HIV infection
- brain ischemia
- Pneumocystosis jiroveci pneumonia
- COVID-19
regulates
- dopamine
- oxygen
- chloride
- carbon dioxide
- GABA-A receptor
role in cell
- density
- development
- degeneration
- assembly
- sprouting angiogenesis by
- response by
- innervation
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- sperm head
- dendritic spines
- synaptosomes
- synapse
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabrb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- cellular response to histamine
- signal transduction
- palate development
- synaptic transmission
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- cytoplasmic vesicle membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- GABA-A receptor activity
- neurotransmitter receptor activity
- chloride channel activity
- GABA-gated chloride ion channel activity