Mapkbp1 Gene Summary [Mouse]
Acts upstream of or within positive regulation of JNK cascade. Predicted to be located in mitotic spindle pole; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in nephronophthisis 20. Orthologous to human MAPKBP1 (mitogen-activated protein kinase binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapkbp1 |
| Official Name | mitogen-activated protein kinase binding protein 1 [Source:MGI Symbol;Acc:MGI:1347004] |
| Ensembl ID | ENSMUSG00000033902 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase binding protein 1 |
| Synonyms | 2810483F24Rik, JNKBP-1, mitogen-activated protein kinase binding protein 1, mKIAA0596, NPHP20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapkbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- nucleoplasm
- nucleoli
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapkbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-8 production
- positive regulation of JNK cascade
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding