Parl Gene Summary [Mouse]
Enables endopeptidase activity. Involved in several processes, including mitochondrial fusion; negative regulation of apoptotic signaling pathway; and regulation of mitophagy. Located in mitochondrial inner membrane. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parl |
| Official Name | presenilin associated, rhomboid-like [Source:MGI Symbol;Acc:MGI:1277152] |
| Ensembl ID | ENSMUSG00000033918 |
| Bio databases IDs | |
| Aliases | presenilin associated, rhomboid-like |
| Synonyms | D16Ertd607e, presenilin associated rhomboid like, presenilin associated, rhomboid-like, PRESENILINS ASSOCIATED RHOMBOID-LIKE, PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Parl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase
- serine endopeptidase
- peptidase
- protein binding
- Rhomboid family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kyphosis
- paresis
- bleeding
- encephalopathy
- growth failure
- Leigh-like encephalopathy
- neurological disorder
- neurodegeneration
- Parkinson disease
- Leigh syndrome
regulated by
- TYA-018
- BAG3
role in cell
- expression in
- apoptosis
- degeneration
- morphology
- quantity
- number
- degradation in
- fusion
- production
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Parl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of release of cytochrome c from mitochondria
- mitochondrial fusion
- regulation of proteolysis
- proteolysis
- membrane protein proteolysis
- regulation of reactive oxygen species metabolic process
- signal peptide processing
- protein processing
- regulation of mitochondrion organization
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- endopeptidase activity