Ttc19 Gene Summary [Mouse]
Predicted to be involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; head; and trigeminal ganglion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Orthologous to human TTC19 (tetratricopeptide repeat domain 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ttc19 |
| Official Name | tetratricopeptide repeat domain 19 [Source:MGI Symbol;Acc:MGI:1920045] |
| Ensembl ID | ENSMUSG00000042298 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 19 |
| Synonyms | 2010204O13RIK, 2810460C24Rik, LOC687312, MC3DN2, RGD1311797, tetratricopeptide repeat domain 19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttc19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- Mitochondria
- midbody
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttc19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex III assembly
- cytokinesis after mitosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- mitochondrion
- midbody
- mitochondrial inner membrane
- respiratory chain
Molecular Function
What the gene product does at the molecular level
- protein binding