Phka1 Gene Summary [Mouse]
Predicted to enable calmodulin binding activity. Predicted to be involved in positive regulation of glycogen catabolic process. Predicted to be located in plasma membrane. Predicted to be part of phosphorylase kinase complex. Is expressed in cerebral cortex; diencephalon lateral wall mantle layer; heart; liver; and midbrain mantle layer. Used to study glycogen storage disease IXd. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease IXd. Orthologous to human PHKA1 (phosphorylase kinase regulatory subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phka1 |
| Official Name | phosphorylase kinase alpha 1 [Source:MGI Symbol;Acc:MGI:97576] |
| Ensembl ID | ENSMUSG00000034055 |
| Bio databases IDs | |
| Aliases | phosphorylase kinase alpha 1 |
| Synonyms | 5330411D17, 9830108K24Rik, Pcyt1b, PHKA, phosphorylase kinase alpha 1, phosphorylase kinase regulatory subunit alpha 1, phosphorylase kinase regulatory subunit α 1, phosphorylase kinase α 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phka1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- choline-phosphate cytidylyltransferase
- protein binding
- phosphorylase kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phka1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- glycogen metabolic process
- positive regulation of glycogen catabolic process
Cellular Component
Where in the cell the gene product is active
- phosphorylase kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphorylase kinase activity
- calmodulin binding