Scn11a Gene Summary [Mouse]
Enables voltage-gated sodium channel activity. Involved in several processes, including behavioral response to chemical pain; detection of stimulus involved in sensory perception of pain; and monoatomic cation transmembrane transport. Acts upstream of or within establishment of localization in cell and sodium ion transport. Located in C-fiber and plasma membrane. Is active in axonal growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and sensory organ. Used to study familial episodic pain syndrome 3 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn11a |
| Official Name | sodium channel, voltage-gated, type XI, alpha [Source:MGI Symbol;Acc:MGI:1345149] |
| Ensembl ID | ENSMUSG00000034115 |
| Bio databases IDs | |
| Aliases | sodium channel, voltage-gated, type XI, alpha |
| Synonyms | FEPS3, HSAN7, LOC105377643, NaN, NaT, NAV1.9, NSS2, PN5, SCN12A, SNS-2, sodium channel, voltage-gated, type XI, alpha, sodium channel, voltage-gated, type XI, α, sodium voltage-gated channel alpha subunit 11, sodium voltage-gated channel α subunit 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scn11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium ion transport-associated
- Voltage-dependent L-type calcium channel, IQ-associated
- voltage-gated sodium channel
- Ion transport protein
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Scn11a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- seizures
- hereditary disorder
- epilepsy
- migraines
- thermal hypalgesia
- familial episodic pain syndrome type 3
- partial seizure without secondary generalization
- amyotrophic lateral sclerosis
- Huntington disease
regulates
- Ca2+
- Na+
role in cell
- motility
- depolarization
- response
- action potential
- development
- transmission
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- cell surface
- cell periphery
- cellular membrane
- presynaptic membrane
- neurites
- perikaryon
- axons
- C fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scn11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to prostaglandin E stimulus
- response to xenobiotic stimulus
- artery development
- mast cell degranulation
- reflex
- response to toxin
- response to heat
- axonogenesis
- thigmotaxis
- protein kinase A signaling cascade
- response to auditory stimulus
- calcium ion transmembrane transport
- thermosensory behavior
- response to nitric oxide
- regulation of action potential in neuron
- regulation of cardiac muscle cell action potential involved in contraction
- behavioral response to acetic acid induced pain
- micturition
- response to high light intensity
- skeletal muscle organ development
- behavioral response to formalin induced pain
- circadian rhythm
- cell motility
- chronic inflammatory response
- acute inflammatory response
- sensory perception of pain
- sodium ion transmembrane transport
- detection of mechanical stimulus involved in sensory perception of pain
- membrane depolarization involved in regulation of action potential
- detection of temperature stimulus involved in sensory perception of pain
- cellular response to cold
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- axonal growth cone
- C-fiber
- voltage-gated sodium channel complex
- neuronal cell body
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated sodium channel activity