Fgf12 Gene Summary [Mouse]
Predicted to enable heparin binding activity; sodium channel regulator activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including adult locomotory behavior; neuromuscular process; and positive regulation of sodium ion transport. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 47. Orthologous to human FGF12 (fibroblast growth factor 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf12 |
| Official Name | fibroblast growth factor 12 [Source:MGI Symbol;Acc:MGI:109183] |
| Ensembl ID | ENSMUSG00000022523 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 12 |
| Synonyms | B230343J05Rik, bc030485, DEE47, EIEE47, FGF12B, Fgf1a, FHF-1, Fhf1b, fibroblast growth factor 12, LOC100505888 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- ion channel binding
- sodium channel regulator
- protein binding
- heparin binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early infantile epileptic encephalopathy type 47
- prostate cancer
- acute myeloid leukemia
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- epithelial cancer
- gastric epithelial cancer
- hepatoid gastric adenocarcinoma
- colon cancer
- angioedema
role in cell
- expression in
- phosphorylation in
- proliferation
- apoptosis
- quantity
- number
- modulation in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- heart development
- signal transduction
- neuromuscular process
- regulation of sodium ion transmembrane transporter activity
- cell-cell signaling
- positive regulation of sodium ion transport
- nervous system development
- synaptic transmission
- adult locomotory behavior
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- synapse
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- growth factor activity
- protein binding
- ion channel binding