Dbn1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in several processes, including positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; and positive regulation of synaptic plasticity. Acts upstream of or within several processes, including cell communication by chemical coupling; cell communication by electrical coupling; and maintenance of protein location in cell. Located in several cellular components, including actin cytoskeleton; gap junction; and growth cone. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbn1 |
| Official Name | drebrin 1 [Source:MGI Symbol;Acc:MGI:1931838] |
| Ensembl ID | ENSMUSG00000034675 |
| Bio databases IDs | |
| Aliases | drebrin 1 |
| Synonyms | D0S117E, Drebrin, drebrin 1, Drebrin E, DREBRIN E2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dbn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- cytoskeletal protein binding
- actin binding
- protein binding
- profilin binding
Pathways
Biological processes and signaling networks where the Dbn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic cardiomyopathy
- Huntington disease
- COVID-19
- pervasive developmental disorder
- tinnitus
- psoriasis
- diarrhea
- hemangioma
- angiomatosis
- passive systemic anaphylaxis
phenotypes
- abnormal allantois morphology
- abnormal chorioallantoic fusion
- abnormal coat appearance
- abnormal embryo size
- abnormal embryo turning
- abnormal facial morphology
- abnormal forebrain development
- abnormal head shape
- abnormal heart morphology
- abnormal hindbrain development
- abnormal liver morphology
- abnormal midbrain development
- abnormal neural tube closure
- abnormal retina morphology
- abnormal vertebrae morphology
- decreased body weight
- decreased caudal vertebrae number
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased circulating free fatty acid level
- decreased circulating fructosamine level
- decreased circulating glycerol level
- decreased circulating iron level
- decreased circulating serum albumin level
- decreased grip strength
- decreased mean platelet volume
- decreased startle reflex
- decreased total body fat amount
- decreased total retina thickness
- enlarged heart
- improved glucose tolerance
- increased CD8-positive alpha-beta T cell number
- increased bone mineral content
- increased bone mineral density
- increased circulating alkaline phosphatase level
- increased circulating magnesium level
- increased circulating phosphate level
- increased fasting circulating glucose level
- increased hematocrit
- increased hemoglobin content
- increased lean body mass
- increased leukocyte cell number
- increased mean corpuscular hemoglobin
- preweaning lethality complete penetrance
- preweaning lethality incomplete penetrance
- abnormal Wolffian duct connection
- abnormal brachial plexus formation
- abnormal brain internal capsule morphology
- abnormal brain white matter morphology
- abnormal cervical rib
- abnormal circulating alkaline phosphatase level
- abnormal dendritic spine morphology
- abnormal forebrain morphology
- abnormal grip strength
- abnormal hippocampus morphology
- abnormal hypoglossal canal morphology
- abnormal lean body mass
- abnormal platelet volume
- abnormal telencephalon morphology
- abnormal total retina thickness
- absent hypoglossal canal
- absent hypoglossal nerve
- decreased circulating LDL cholesterol level
- decreased circulating alanine transaminase level
- decreased circulating aspartate transaminase level
- decreased circulating calcium level
- decreased circulating total protein level
- decreased mean corpuscular volume
- enlarged liver sinusoidal spaces
- impaired cued conditioning behavior
- impaired synaptic plasticity
- increased circulating chloride level
- increased red blood cell distribution width
- thin hypoglossal nerve
role in cell
- differentiation
- expression in
- migration
- formation
- architecture
- growth
- calcium response
- organization
- assembly
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- cortical cytoskeleton
- axon component
- cytoskeleton
- cell surface
- basal region of growth cone
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- actin filaments
- intercellular junctions
- postsynaptic membrane
- dendritic spines
- growth cone
- neurites
- synaptosomes
- synapse
- actin stress fibers
- gap junctions
- pseudopodia
- filopodia
- cell membrane leading edge
- postsynaptic spines
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dbn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine morphogenesis
- neural precursor cell proliferation
- actin filament organization
- generation of neurons
- regulation of dendrite development
- maintenance of protein location in cell
- cytoplasmic sequestering of protein
- in utero embryonic development
- regulation of neuronal synaptic plasticity
- positive regulation of synaptic plasticity
- cell communication by electrical coupling
- cell communication by chemical coupling
Cellular Component
Where in the cell the gene product is active
- growth cone
- gap junction
- dendrite
- postsynaptic density
- cytoskeleton
- postsynaptic membrane
- cytoplasm
- actin cytoskeleton
- actomyosin
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- profilin binding