Dbn1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in several processes, including positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; and positive regulation of synaptic plasticity. Acts upstream of or within several processes, including cell communication by chemical coupling; cell communication by electrical coupling; and maintenance of protein location in cell. Located in several cellular components, including actin cytoskeleton; gap junction; and growth cone. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbn1 |
| Official Name | drebrin 1 [Source:MGI Symbol;Acc:MGI:1931838] |
| Ensembl ID | ENSMUSG00000034675 |
| Bio databases IDs | |
| Aliases | drebrin 1 |
| Synonyms | D0S117E, Drebrin, drebrin 1, Drebrin E, DREBRIN E2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dbn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- cytoskeletal protein binding
- actin binding
- protein binding
- profilin binding
Pathways
Biological processes and signaling networks where the Dbn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic cardiomyopathy
- Huntington disease
- COVID-19
- pervasive developmental disorder
- tinnitus
- psoriasis
- diarrhea
- hemangioma
- angiomatosis
- passive systemic anaphylaxis
role in cell
- differentiation
- expression in
- migration
- formation
- architecture
- growth
- calcium response
- organization
- assembly
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- cortical cytoskeleton
- axon component
- cytoskeleton
- cell surface
- basal region of growth cone
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- actin filaments
- intercellular junctions
- postsynaptic membrane
- dendritic spines
- growth cone
- neurites
- synaptosomes
- synapse
- actin stress fibers
- gap junctions
- pseudopodia
- filopodia
- cell membrane leading edge
- postsynaptic spines
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dbn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine morphogenesis
- neural precursor cell proliferation
- actin filament organization
- generation of neurons
- regulation of dendrite development
- maintenance of protein location in cell
- cytoplasmic sequestering of protein
- in utero embryonic development
- regulation of neuronal synaptic plasticity
- positive regulation of synaptic plasticity
- cell communication by electrical coupling
- cell communication by chemical coupling
Cellular Component
Where in the cell the gene product is active
- growth cone
- gap junction
- dendrite
- postsynaptic density
- cytoskeleton
- postsynaptic membrane
- cytoplasm
- actin cytoskeleton
- actomyosin
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- profilin binding