Atoh1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in negative regulation of gliogenesis; positive regulation of inner ear receptor cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including generation of neurons; neuroblast migration; and positive regulation of inner ear auditory receptor cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; inner ear; and skin. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 89. Orthologous to human ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atoh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Atoh1 gene, providing context for its role in the cell.