Igsf9b Gene Summary [Mouse]
Enables kinase binding activity. Involved in synaptic membrane adhesion. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules and positive regulation of inhibitory postsynaptic potential. Located in dendrite; inhibitory synapse; and neuronal cell body. Is active in GABA-ergic synapse. Is expressed in hippocampus CA1 and thalamic nucleus. Orthologous to human IGSF9B (immunoglobulin superfamily member 9B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igsf9b |
| Official Name | immunoglobulin superfamily, member 9B [Source:MGI Symbol;Acc:MGI:2685354] |
| Ensembl ID | ENSMUSG00000034275 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily, member 9B |
| Synonyms | AI414108, AI854107, BC061253, Gm508, immunoglobulin superfamily member 9B, immunoglobulin superfamily, member 9B, KIAA1030, LINC00947, LOC283174, LOC646543, MIR4697HG, mKIAA1030, RGD1564717 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igsf9b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- FN3
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anxiety disorder
- schizophrenia
- insomnia
- epileptic seizure
- neuroticism
- major depression
- bipolar disorder
- cardiomyopathy
- Parkinson disease
- alcoholism
regulates
role in cell
- adhesion
- development
- clustering in
- development in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- organelle
- synaptic membrane
- synaptosomes
- synapse
- perikaryon
- dendrites
- inhibitory synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igsf9b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- postsynaptic membrane
- neuron projection