Tec Gene Summary [Mouse]
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in adaptive immune response; cell surface receptor signaling pathway; and regulation of platelet activation. Located in cell-cell junction. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and retina. Orthologous to human TEC (tec protein tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tec |
| Official Name | tec protein tyrosine kinase [Source:MGI Symbol;Acc:MGI:98662] |
| Ensembl ID | ENSMUSG00000029217 |
| Bio databases IDs | |
| Aliases | tec protein tyrosine kinase |
| Synonyms | PSCTK4, tec protein tyrosine kinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tec often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Tec homology domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- non-membrane spanning protein tyrosine kinase
- protein binding
- Pleckstrin homology-like domain
- protein-tyrosine kinase
- Protein kinase domain
- proline rich domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- BTK motif
- PH domain
- Src homology 2 (SH2) domain
- SH1 domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Tec gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- mixed neoplasm with eosinophilia
- precursor B-cell acute lymphoblastic leukemia
- organismal death
- rheumatoid arthritis
- chronic phase chronic myeloid leukemia
- chronic myeloid leukemia
- advanced phase chronic myeloid leukemia
- accelerated phase chronic myelogenous leukemia
- alopecia areata
regulated by
- adenosine triphosphate
- wortmannin
- Pertussis toxin
- prostaglandin E2
- SB203580
- N-formyl-Met-Leu-Phe
- Tec-IN-14
- PI3K (complex)
- phosphatidylinositol-3,4,5-triphosphate
- VAV1
role in cell
- activation
- proliferation
- quantity
- phosphorylation in
- apoptosis
- aggregation
- growth
- number
- differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Plasma Membrane
- intercellular junctions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tec gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- integrin-mediated signaling pathway
- adaptive immune response
- protein phosphorylation
- tissue regeneration
- intracellular signal transduction
- regulation of platelet activation
- T cell receptor signaling pathway
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- phospholipid binding