Ube2f Gene Summary [Mouse]

Enables NEDD8 transferase activity. Involved in protein neddylation. Predicted to be active in cytosol and nucleus. Orthologous to human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Retained Intron
Official Symbol
Ube2f
Official Name
ubiquitin-conjugating enzyme E2F (putative) [Source:MGI Symbol;Acc:MGI:1915171]
Ensembl ID
ENSMUSG00000034343
Bio databases IDs NCBI: 67921 Ensembl: ENSMUSG00000034343
Aliases ubiquitin-conjugating enzyme E2F (putative)
Synonyms 2510010F15RIK, NCE2, RGD1307608, ubiquitin-conjugating enzyme E2F (putative)
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • NEDD8 ligase
  • Ubiquitin-conjugating enzyme
  • ubiquitin-like protein transferase activity
  • UBCc_UEV
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the Ube2f gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • septic shock
  • ovarian carcinoma
  • epithelial ovarian cancer
regulated by
  • SYK/ZAP
  • niacinamide
  • CEBPB
  • NP-KLH
regulates
role in cell
  • degradation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2f gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein neddylation
  • post-translational protein modification

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • protein binding
  • NEDD8 ligase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.