UBE2F Gene Summary [Human]
Enables NEDD8 conjugating enzyme activity. Involved in protein neddylation. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | UBE2F |
| Official Name | ubiquitin conjugating enzyme E2 F (putative) [Source:HGNC Symbol;Acc:HGNC:12480] |
| Ensembl ID | ENSG00000184182 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 F (putative), NEDD8 conjugating enzyme |
| Synonyms | 2510010F15RIK, NCE2, RGD1307608, ubiquitin-conjugating enzyme E2F (putative) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEDD8 ligase
- Ubiquitin-conjugating enzyme
- ubiquitin-like protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2F gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein neddylation
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- NEDD8 ligase activity