Barhl2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within several processes, including generation of neurons; positive regulation of macromolecule biosynthetic process; and regulation of axon extension. Located in nucleus. Is expressed in several structures, including alimentary system epithelium; eye; future brain; and nervous system. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BARHL2 (BarH like homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Barhl2 |
| Official Name | BarH like homeobox 2 [Source:MGI Symbol;Acc:MGI:1859314] |
| Ensembl ID | ENSMUSG00000034384 |
| Bio databases IDs | |
| Aliases | BarH like homeobox 2 |
| Synonyms | Barh, BarH-class homeodomain transcription factor, BarH-like homeobox 2, E130309B19Rik, MBH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Barhl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Barhl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amacrine cell differentiation
- neuron migration
- regulation of axon extension
- positive regulation of translation
- positive regulation of transcription from RNA polymerase II promoter
- cell fate determination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity