Plekhf2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endosome organization and endosome to lysosome transport. Predicted to be located in transport vesicle. Predicted to be active in early endosome. Is expressed in central nervous system and genitourinary system. Orthologous to human PLEKHF2 (pleckstrin homology and FYVE domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhf2 |
| Official Name | pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Source:MGI Symbol;Acc:MGI:1919051] |
| Ensembl ID | ENSMUSG00000049969 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family F (with FYVE domain) member 2 |
| Synonyms | 1110070J07RIK, EAPF, PHAFIN2, pleckstrin homology and FYVE domain containing 2, pleckstrin homology domain containing, family F (with FYVE domain) member 2, ZFYVE18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PH domain
- PHD finger superfamily
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- protein transport
- endosome to lysosome transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- endoplasmic reticulum
- transport vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphatidylinositol binding