Dhrs11 Gene Summary [Mouse]
Predicted to enable 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in steroid biosynthetic process. Predicted to be located in extracellular region. Is expressed in liver lobe. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhrs11 |
| Official Name | dehydrogenase/reductase (SDR family) member 11 [Source:MGI Symbol;Acc:MGI:2652816] |
| Ensembl ID | ENSMUSG00000034449 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase (SDR family) member 11 |
| Synonyms | ARPG836, dehydrogenase/reductase 11, MGC4172, RGD1307935, SDR24C1, spDHRS11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhrs11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 3-keto sterol reductase
- estradiol 17beta-dehydrogenase
- SDR family mycofactocin-dependent oxidoreductase
- NAD dependent epimerase/dehydratase family
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- NAD(P)H-binding
- sepiapterin reductase
- CH-OH group:NAD or NADP oxidoreductase
- short chain dehydrogenase
- steroid dehydrogenase
Pathways
Biological processes and signaling networks where the Dhrs11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhrs11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- estradiol 17-beta-dehydrogenase activity
- 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
- 3-keto sterol reductase activity
- 17-beta-ketosteroid reductase activity