Cyren Gene Summary [Mouse]
Enables damaged DNA binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; positive regulation of double-strand break repair via nonhomologous end joining; and protein localization to site of double-strand break. Part of DNA repair complex. Is active in site of double-strand break. Is expressed in several structures, including adipose tissue; alimentary system; eye; male reproductive gland or organ; and nervous system. Orthologous to human CYREN (cell cycle regulator of NHEJ). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyren |
| Official Name | cell cycle regulator of NHEJ [Source:MGI Symbol;Acc:MGI:1925662] |
| Ensembl ID | ENSMUSG00000046806 |
| Bio databases IDs | |
| Aliases | cell cycle regulator of NHEJ |
| Synonyms | 3110062M04Rik, C7orf49, cell cycle regulator of NHEJ, CYREN-1, CYREN-2, LOC653739, MRI, MRI-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyren often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Modulator of retrovirus infection
- damaged DNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyren gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of double-strand break repair via nonhomologous end joining
- immunoglobulin V(D)J recombination
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding