Pof1b Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; bicellular tight junction assembly; and epithelial cell morphogenesis. Predicted to be located in desmosome. Predicted to be active in actin filament; adherens junction; and bicellular tight junction. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 2B. Orthologous to human POF1B (POF1B actin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pof1b |
| Official Name | premature ovarian failure 1B [Source:MGI Symbol;Acc:MGI:1916943] |
| Ensembl ID | ENSMUSG00000034607 |
| Bio databases IDs | |
| Aliases | premature ovarian failure 1B |
| Synonyms | 2310066B14Rik, FLJ22792, POF, POF1B actin binding protein, POF1B, actin binding protein, POF2B, premature ovarian failure 1B, RGD1560798 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pof1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Afadin- and alpha -actinin-Binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Mitochondria
- actin filaments
- desmosomes
- tight junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pof1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tight junction assembly
- epithelial cell morphogenesis
- actin filament organization
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- adherens junction
- tight junction
- desmosome
- actin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding