Frs3 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; gut; immune system; lung; and metanephros. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frs3 |
| Official Name | fibroblast growth factor receptor substrate 3 [Source:MGI Symbol;Acc:MGI:2135965] |
| Ensembl ID | ENSMUSG00000023266 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor substrate 3 |
| Synonyms | 4930417B13RIK, fibroblast growth factor receptor substrate 3, FRS2B, FRS2-beta, FRS2-β, SNT-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- fibroblast growth factor receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- fibroblast growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- fibroblast growth factor receptor binding