Fndc5 Gene Summary [Mouse]
This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | Fndc5 |
| Official Name | fibronectin type III domain containing 5 [Source:MGI Symbol;Acc:MGI:1917614] |
| Ensembl ID | ENSMUSG00000001334 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 5 |
| Synonyms | 1500001L03Rik, D1MGI29, fibronectin type III domain containing 5, FRCP2, irisin, LOC260327, PeP, PXP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fndc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
- diabetes mellitus
- preeclampsia
- high-fat diet-induced obesity
- motor dysfunction
- Alzheimer disease
- end stage renal disease
- intrauterine growth retardation
- interstitial fibrosis
- osteolysis
role in cell
- expression in
- apoptosis
- cell death
- migration
- production in
- proliferation
- quantity
- invasion by
- morphology
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fndc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- positive regulation of brown fat cell differentiation
- signal transduction
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hormone activity