Gmcl1 Gene Summary [Mouse]
Predicted to enable cullin family protein binding activity and identical protein binding activity. Acts upstream of or within regulation of DNA-templated transcription. Located in nuclear envelope and nuclear matrix. Is expressed in several structures, including cerebral cortex; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including GMCL1 (germ cell-less 1, spermatogenesis associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmcl1 |
| Official Name | germ cell-less, spermatogenesis associated 1 [Source:MGI Symbol;Acc:MGI:1345156] |
| Ensembl ID | ENSMUSG00000001157 |
| Bio databases IDs | |
| Aliases | germ cell-less, spermatogenesis associated 1 |
| Synonyms | 2810049L19RIK, BTBD13, DIP, GCL, GCL1, germ cell-less 1, spermatogenesis associated, germ cell-less, spermatogenesis associated 1, glc-1, mglc-1, SPATA29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atrial fibrillation
- cardioembolic stroke
- oligozoospermia
- teratozoospermia
- endometrium tumor
- asthenozoospermia
- globozoospermia
role in cell
- morphology
- abnormal morphology
- condensation
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear envelope
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding