Nagk Gene Summary [Mouse]
Enables N-acetylglucosamine kinase activity; N-acylmannosamine kinase activity; and muramyl dipeptide kinase activity. Involved in positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Acts upstream of or within N-acetylglucosamine metabolic process. Is expressed in several structures, including eye; genitourinary system; liver; nervous system; and spleen. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nagk |
| Official Name | N-acetylglucosamine kinase [Source:MGI Symbol;Acc:MGI:1860418] |
| Ensembl ID | ENSMUSG00000034744 |
| Bio databases IDs | |
| Aliases | N-acetylglucosamine kinase |
| Synonyms | GNK, HSA242910, N-acetylglucosamine kinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nagk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- N-acylmannosamine kinase
- N-acetylglucosamine kinase
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- neoplasia
- acute graft-vs-host disease
- atopic dermatitis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- systemic sclerosis
regulates
- N-acetylneuraminic acid
- N-acetylglucosamine
- N-acetylmannosamine
- STK16
- UDP-N-acetylglucosamine
role in cell
- branching
- branching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- vesicles
- cytosol
- filopodia
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nagk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muramyl dipeptide
- N-acetylneuraminate catabolic process
- N-acetylmannosamine metabolic process
- innate immune response
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- N-acetylglucosamine metabolic process
- carbohydrate phosphorylation
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- N-acetylglucosamine kinase activity