Colgalt1 Gene Summary [Mouse]
Predicted to enable procollagen galactosyltransferase activity. Predicted to be involved in positive regulation of collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Is expressed in axial skeleton and embryo. Human ortholog(s) of this gene implicated in brain small vessel disease 3. Orthologous to human COLGALT1 (collagen beta(1-O)galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Colgalt1 |
| Official Name | collagen beta(1-O)galactosyltransferase 1 [Source:MGI Symbol;Acc:MGI:1924348] |
| Ensembl ID | ENSMUSG00000034807 |
| Bio databases IDs | |
| Aliases | collagen beta(1-O)galactosyltransferase 1 |
| Synonyms | 2810024B22Rik, BSVD3, collagen beta(1-O)galactosyltransferase 1, collagen β(1-O)galactosyltransferase 1, GLT25D1, MGC38524, RGD1309002 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Colgalt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family 2
- Glyco_transf_25
- procollagen galactosyltransferase
- enzyme
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- brain small vessel disease type 3
- colorectal cancer
- growth failure
- hereditary disorder
role in cell
- proliferation
- expression in
- accumulation in
- abnormal morphology
- organization
- glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Colgalt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- membrane
Molecular Function
What the gene product does at the molecular level
- procollagen galactosyltransferase activity