Tespa1 Gene Summary [Mouse]
Enables phospholipase binding activity. Involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within TCR signalosome assembly. Located in cytoplasm. Part of TCR signalosome. Is expressed in ductus deferens; testis; thymus; and thymus primordium. Orthologous to human TESPA1 (thymocyte expressed, positive selection associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tespa1 |
| Official Name | thymocyte expressed, positive selection associated 1 [Source:MGI Symbol;Acc:MGI:1914846] |
| Ensembl ID | ENSMUSG00000034833 |
| Bio databases IDs | |
| Aliases | thymocyte expressed, positive selection associated 1 |
| Synonyms | 5830405N20Rik, A430001F24Rik, HSPC257, ITPRID3, KIAA0748, thymocyte expressed, positive selection associated 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tespa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ki-ras-induced actin-interacting protein-IP3R-interacting domain
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eczema
- respiratory disorder
- allergic asthma
- atopic dermatitis
- asthma
- diabetic nephropathy
role in cell
- differentiation
- activation in
- proliferation
- number
- abnormal morphology
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tespa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell receptor signaling pathway
- positive regulation of T cell differentiation in thymus
- T cell differentiation in thymus
- protein localization
- signalosome assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- cytosol
- signalosome
Molecular Function
What the gene product does at the molecular level
- phospholipase binding
- receptor binding