Cog3 Gene Summary [Mouse]
Predicted to be involved in several processes, including Golgi vesicle transport; protein glycosylation; and protein stabilization. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of Golgi transport complex. Is expressed in several structures, including brain; pancreas; and reproductive system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIbb. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cog3 |
| Official Name | component of oligomeric golgi complex 3 [Source:MGI Symbol;Acc:MGI:2450151] |
| Ensembl ID | ENSMUSG00000034893 |
| Bio databases IDs | |
| Aliases | component of oligomeric golgi complex 3 |
| Synonyms | CDG2BB, component of oligomeric golgi complex 3, E430004N23, SEC34 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cog3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Sec34-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type IIbb
- susceptibility to amyotrophic lateral sclerosis
- congenital disorders of glycosylation
- infection by HIV-1
regulated by
- mir-146 (includes others)
- brefeldin A
- XBP1
regulates
role in cell
- disruption
- fragmentation
- organization
- vesicle transport in
- fragmentation in
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- Golgi stacks
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cog3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- Golgi organization
- protein glycosylation
- intra-Golgi vesicle-mediated transport
- protein localization to organelle
- intracellular protein transport
- protein stabilization
- retrograde transport, vesicle recycling within Golgi
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- cis-Golgi network
- Golgi cisterna membrane
- cytosol
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding