Cog2 Gene Summary [Mouse]
Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to be located in Golgi stack. Predicted to be part of Golgi transport complex. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Orthologous to human COG2 (component of oligomeric golgi complex 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cog2 |
| Official Name | component of oligomeric golgi complex 2 [Source:MGI Symbol;Acc:MGI:1923582] |
| Ensembl ID | ENSMUSG00000031979 |
| Bio databases IDs | |
| Aliases | component of oligomeric golgi complex 2 |
| Synonyms | 1190002B08Rik, 2700012E02Rik, CDG2Q, component of oligomeric golgi complex 2, LDLC, LOC678914 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cog2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- COG complex component, COG2, C-terminal
- COG (conserved oligomeric Golgi) complex component, COG2
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 2q
- ulcerative colitis
- infection by HIV-1
role in cell
- organization
- vesicle transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- Golgi stacks
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cog2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- Golgi organization
- protein transport
- intra-Golgi vesicle-mediated transport
- retrograde transport, vesicle recycling within Golgi
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- Golgi membrane
- Golgi stack
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding