COG3 Gene Summary [Human]
This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
Details
| Type | Processed Transcript |
| Official Symbol | COG3 |
| Official Name | component of oligomeric golgi complex 3 [Source:HGNC Symbol;Acc:HGNC:18619] |
| Ensembl ID | ENSG00000136152 |
| Bio databases IDs | |
| Aliases | component of oligomeric golgi complex 3 |
| Synonyms | CDG2BB, component of oligomeric golgi complex 3, E430004N23, SEC34 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Sec34-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type IIbb
- susceptibility to amyotrophic lateral sclerosis
- congenital disorders of glycosylation
- infection by HIV-1
regulated by
- mir-146 (includes others)
- brefeldin A
- XBP1
regulates
role in cell
- disruption
- fragmentation
- organization
- vesicle transport in
- fragmentation in
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- Golgi stacks
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- Golgi organization
- protein glycosylation
- intra-Golgi vesicle-mediated transport
- protein localization to organelle
- intracellular protein transport
- protein stabilization
- retrograde transport, vesicle recycling within Golgi
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- cis-Golgi network
- Golgi cisterna membrane
- cytosol
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding