Rims4 Gene Summary [Mouse]
Enables transmembrane transporter binding activity. Acts upstream of or within regulation of membrane potential. Located in synaptic membrane. Is expressed in central nervous system and retina. Orthologous to human RIMS4 (regulating synaptic membrane exocytosis 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rims4 |
| Official Name | regulating synaptic membrane exocytosis 4 [Source:MGI Symbol;Acc:MGI:2674366] |
| Ensembl ID | ENSMUSG00000035226 |
| Bio databases IDs | |
| Aliases | regulating synaptic membrane exocytosis 4 |
| Synonyms | 6530406L02, C20orf190, regulating synaptic membrane exocytosis 4, RIM-4, RIM4-gamma, RIM4-γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rims4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel binding
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- synaptic membrane
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rims4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis of neurotransmitter
- regulation of membrane potential
- positive regulation of synaptic transmission
- regulation of synaptic plasticity
- regulation of synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- presynaptic active zone
- presynaptic cytoskeletal matrix assembled at active zones
- synaptic membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- ion channel binding