Nr2f2 Gene Summary [Mouse]
Enables sequence-specific DNA binding activity. Involved in lymph vessel development. Acts upstream of or within several processes, including blood vessel development; nervous system development; and regionalization. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diaphragmatic hernia and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr2f2 |
| Official Name | nuclear receptor subfamily 2, group F, member 2 [Source:MGI Symbol;Acc:MGI:1352452] |
| Ensembl ID | ENSMUSG00000030551 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 2, group F, member 2 |
| Synonyms | 2700033K02RIK, 9430015G03Rik, Aporp1, ARP-1, CHTD4, COUP-TF2, COUPTFB, COUP-TFII, Coup TFIIb, EAR3, NF-E3, nuclear receptor subfamily 2 group F member 2, nuclear receptor subfamily 2, group F, member 2, SRXX5, SVP40, Tcfcoup2, TFCOUP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nr2f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- helical domain
- AF-2 transcription activation domain
- retinoid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- binding protein
- ligand-binding domain
- ligand-dependent nuclear receptor
- hinge domain
- protein homodimerization
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nr2f2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- cancer
- 46, XY disorders of sex development
- bleeding
- multiple types congenital heart defects type 4
- uterine leiomyoma
- leiomyomatosis
- metastasis
- organismal death
- prostate cancer
role in cell
- expression in
- activation in
- proliferation
- production in
- migration
- differentiation
- migration by
- network formation by
- transactivation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nr2f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- anatomical structure development
- blood vessel morphogenesis
- female gonad development
- radial pattern formation
- positive regulation of transcription from RNA polymerase II promoter
- maternal placenta development
- negative regulation of transcription from RNA polymerase II promoter
- forebrain development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- trophoblast giant cell differentiation
- negative regulation of endothelial cell migration
- intracellular receptor mediated signaling pathway
- placenta blood vessel development
- positive regulation of systemic arterial blood pressure
- fertilization
- negative regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
- lymphatic endothelial cell fate commitment
- skeletal muscle tissue development
- response to estradiol stimulus
- cell differentiation
- negative regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding