Wdr83 Gene Summary [Mouse]
Acts upstream of or within several processes, including neural tube closure; placenta blood vessel development; and regulation of canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; decidua; extraembryonic component; islets of Langerhans; and renal proximal tubule. Orthologous to human WDR83 (WD repeat domain 83). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Wdr83 |
| Official Name | WD repeat domain containing 83 [Source:MGI Symbol;Acc:MGI:1915086] |
| Ensembl ID | ENSMUSG00000005150 |
| Bio databases IDs | |
| Aliases | WD repeat domain containing 83 |
| Synonyms | 1500041N16Rik, MORG1, RGD1306947, WD repeat domain 83, WD repeat domain containing 83 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr83 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder carcinoma
- familial hypercholanemia
- neurodevelopmental disorder with variable familial hypercholanemia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- cervical squamous cell carcinoma
- squamous cell cervical cancer
regulated by
- imiquimod
- IFNGR1
- NOMO
regulates
- IL6
- MTORC1
role in cell
- activation in
- migration
- proliferation
- splicing by
- replication in
- autophagic flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Cytoplasm
- endosomal membrane
- spliceosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr83 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- response to hypoxia
- regulation of I-kappaB kinase/NF-kappaB cascade
- response to lipopolysaccharide
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- catalytic step 2 spliceosome
- spliceosomal complex
- endosome membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding