Aamdc Gene Summary [Mouse]
Acts upstream of or within negative regulation of apoptotic process; positive regulation of fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human AAMDC (adipogenesis associated Mth938 domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aamdc |
| Official Name | adipogenesis associated Mth938 domain containing [Source:MGI Symbol;Acc:MGI:1913523] |
| Ensembl ID | ENSMUSG00000035642 |
| Bio databases IDs | |
| Aliases | adipogenesis associated Mth938 domain containing |
| Synonyms | 1810020D17Rik, 1810037D19Rik, adipogenesis associated Mth938 domain containing, adipogenesis associated, Mth938 domain containing, BC026557, C11orf67, CK067, LI2, PTD015, RGD1561459 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aamdc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF498/DUF598)
- Mth938-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Graves disease
- thyrotoxic periodic paralysis
regulated by
- lipopolysaccharide
- B lymphocytes
- metformin
- topotecan
- ammonium
- RYR1
role in cell
- apoptosis
- expression in
- phosphorylation in
- differentiation
- everolimus sensitivity
- dactolisib sensitivity
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aamdc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding