Eif4ebp1 Gene Summary [Mouse]
Enables eukaryotic initiation factor 4E binding activity. Involved in IRES-dependent translational initiation of linear mRNA. Acts upstream of or within cellular response to dexamethasone stimulus; insulin receptor signaling pathway; and negative regulation of translational initiation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including central nervous system; oocyte; pancreas tip epithelium; skeletal musculature; and thymus. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4ebp1 |
| Official Name | eukaryotic translation initiation factor 4E binding protein 1 [Source:MGI Symbol;Acc:MGI:103267] |
| Ensembl ID | ENSMUSG00000031490 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E binding protein 1 |
| Synonyms | 4E-BP1, BP-1, Eukaryotic translation initiation factor 4e binding protein 1, PHAS-I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4ebp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RAIP motif
- translation repressor
- protein phosphatase binding
- Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
- protein binding
- eIF4E binding domain
- eukaryotic initiation factor 4E binding
- TOS domain
- translation regulator
- phosphorylation site
Pathways
Biological processes and signaling networks where the Eif4ebp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- AMPK Signaling
- Circadian Rhythm Signaling
- ERK/MAPK Signaling
- Estrogen Receptor Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- HIF1α Signaling
- IL-4 Signaling
- IL-8 Signaling
- Insulin Receptor Signaling
- mTOR Signaling
- Regulation of eIF4 and p70S6K Signaling
- Serotonin Receptor Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- abdominal cancer
- schizophrenia
- bipolar disorder
- liver cancer
- diabetes mellitus
role in cell
- expression in
- phosphorylation in
- proliferation
- function
- activation in
- apoptosis
- migration
- production in
- upregulation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- cytosol
- P-body granule
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4ebp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- G1/S transition of mitotic cell cycle
- TOR signaling cascade
- negative regulation of translation
- positive regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation repressor activity
- translation initiation factor binding
- eukaryotic initiation factor 4E binding