Gdap1 Gene Summary [Mouse]
Acts upstream of or within response to retinoic acid. Predicted to be located in cytosol and mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including future brain; ileum; male reproductive gland or organ; and nervous system. Used to study Charcot-Marie-Tooth disease axonal type 2K. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; Charcot-Marie-Tooth disease axonal type 2K; Charcot-Marie-Tooth disease recessive intermediate A; Charcot-Marie-Tooth disease type 4A; and autosomal recessive axonal Charcot-Marie-Tooth disease with vocal cord paresis. Orthologous to human GDAP1 (ganglioside induced differentiation associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdap1 |
| Official Name | ganglioside-induced differentiation-associated-protein 1 [Source:MGI Symbol;Acc:MGI:1338002] |
| Ensembl ID | ENSMUSG00000025777 |
| Bio databases IDs | |
| Aliases | ganglioside-induced differentiation-associated-protein 1 |
| Synonyms | CMT4, CMT4A, CMTRIA, ganglioside-induced differentiation-associated-protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gdap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- peripheral neuropathy
- Charcot-Marie-Tooth disease type 4A
- Charcot-Marie-Tooth disease
- endometriosis
- hereditary disorder
- COVID-19
- Charcot-Marie-Tooth disease recessive intermediate type A
- axonal form Charcot-Marie-Tooth disease type 4A
- autosomal recessive Charcot-Marie-Tooth disease axonal type 2K
regulates
- Ca2+
- DNM1L
role in cell
- abnormal morphology
- morphology
- action potential
- outgrowth
- fusion
- fragmentation
- degeneration
- mobilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- cytosol
- mitochondrial outer membrane
- peroxisome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gdap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- response to retinoic acid
- mitochondrial fusion
- cellular response to vitamin D
- mitochondrial fission
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- nucleus
- membrane
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding