Lrfn5 Gene Summary [Mouse]
Involved in negative regulation of macrophage activation and regulation of presynapse assembly. Located in cell surface. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina. Orthologous to human LRFN5 (leucine rich repeat and fibronectin type III domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Lrfn5 |
| Official Name | leucine rich repeat and fibronectin type III domain containing 5 [Source:MGI Symbol;Acc:MGI:2144814] |
| Ensembl ID | ENSMUSG00000035653 |
| Bio databases IDs | |
| Aliases | leucine rich repeat and fibronectin type III domain containing 5 |
| Synonyms | AI427653, C130061B21, C14orf146, FIGLER8, leucine rich repeat and fibronectin type III domain containing 5, LOC100360181, mKIAA4208, SALM5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrfn5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Leucine rich repeat
- Immunoglobulin I-set domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- refractive error
- alcoholic liver disease
- generalized anxiety disorder
- organismal death
- anxiety disorder
- myopia
role in cell
- activation
- expression in
- degradation in
- proliferation
- cell viability
- assembly
- adhesion
- sphere formation by
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- cell surface
- cellular membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrfn5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of macrophage activation
- negative regulation of inflammatory response
Cellular Component
Where in the cell the gene product is active
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding