Pax7 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in skeletal muscle satellite cell differentiation. Acts upstream of or within several processes, including nervous system development; positive regulation of myoblast proliferation; and skeletal system development. Is active in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pax7 |
| Official Name | paired box 7 [Source:MGI Symbol;Acc:MGI:97491] |
| Ensembl ID | ENSMUSG00000028736 |
| Bio databases IDs | |
| Aliases | paired box 7 |
| Synonyms | CMYO19, CMYP19, HUP1, LOC284530, MYOSCO, paired box 7, PAX7B, RGD1564360, RMS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pax7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Paired box protein 7
- transcription regulator
- Eh1 motif
- HTH_ARSR
- protein binding
- sequence-specific DNA binding
- HTH_CRP
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- 'Paired box' domain
- homeodomain
- transcription factor activity
- Paired Box domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- psoriasis
- rhabdomyosarcoma
- muscle weakness
- Ewing sarcoma
- progressive congenital myopathy with scoliosis
- fibrosis
- diabetes mellitus
- cleft lip
- tic disorder
role in cell
- quantity
- expression in
- proliferation
- apoptosis
- differentiation
- colony formation
- disorganization
- organization
- commitment by
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pax7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- satellite cell differentiation
- anatomical structure development
- anatomical structure morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity