Gtf3c4 Gene Summary [Mouse]
Predicted to enable DNA binding activity; RNA polymerase III general transcription initiation factor activity; and histone acetyltransferase activity. Predicted to be involved in chromatin remodeling and transcription initiation at RNA polymerase III promoter. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in limb. Orthologous to human GTF3C4 (general transcription factor IIIC subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf3c4 |
| Official Name | general transcription factor IIIC, polypeptide 4 [Source:MGI Symbol;Acc:MGI:2138937] |
| Ensembl ID | ENSMUSG00000035666 |
| Bio databases IDs | |
| Aliases | general transcription factor IIIC, polypeptide 4 |
| Synonyms | 5330400C03, AI426938, general transcription factor IIIC, polypeptide 4, general transcription factor IIIC subunit 4, KAT12, LOC687576, TF3C-delta, TF3C-δ, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtf3c4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor IIIC subunit delta N-term
- transcription regulator
- histone acetyltransferase
- Putative zinc-finger of transcription factor IIIC complex
- Domain of unknown function (DUF5921)
- protein binding
Pathways
Biological processes and signaling networks where the Gtf3c4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtf3c4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- 5S class rRNA transcription from RNA polymerase III type 1 promoter
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- transcription factor TFIIIC complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- histone acetyltransferase activity
- protein binding
- enzyme activator activity
- core RNA polymerase III binding transcription factor activity