Nfatc2

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in cartilage development; negative regulation of transcription by RNA polymerase II; and positive regulation of gene expression. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; lncRNA transcription; and positive regulation of myoblast fusion. Located in chromatin; cytosol; and nucleus. Part of ribonucleoprotein complex and transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; lung; and thymus primordium. Orthologous to human NFATC2 (nuclear factor of activated T cells 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfatc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Nfatc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfatc2 gene, providing context for its role in the cell.