Arhgap45 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap45 |
| Official Name | Rho GTPase activating protein 45 [Source:MGI Symbol;Acc:MGI:1917969] |
| Ensembl ID | ENSMUSG00000035697 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 45 |
| Synonyms | 6330406L22Rik, HA-1, HLA-HA1, HMHA1, RGD1308662, Rho GTPase activating protein 45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- GTPase activator
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- azurophil granule lumen
- Extracellular Space
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane
- ruffle membrane
- cytosol
- secretory granule lumen
- extracellular region
- azurophil granule lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity