Trim50 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within regulation of establishment of protein localization. Located in aggresome. Is expressed in brain; liver; and reproductive system. Orthologous to human TRIM50 (tripartite motif containing 50). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim50 |
| Official Name | tripartite motif-containing 50 [Source:MGI Symbol;Acc:MGI:2664992] |
| Ensembl ID | ENSMUSG00000053388 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 50 |
| Synonyms | TRIM50A, tripartite motif-containing 50 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- zinc finger of C3HC4-type, RING
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- androgenic alopecia
- gastric cancer
- diabetic nephropathy
- hypochlorhydria
regulated by
- HeLa cells
role in cell
- activation in
- growth
- ubiquitination in
- migration
- abnormal morphology
- innate immune response in
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding