Nrp1 Gene Summary [Mouse]
Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including cell surface receptor signaling pathway; nervous system development; and vasculature development. Acts upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and nervous system development. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Nrp1 |
| Official Name | neuropilin 1 [Source:MGI Symbol;Acc:MGI:106206] |
| Ensembl ID | ENSMUSG00000025810 |
| Bio databases IDs | |
| Aliases | neuropilin 1 |
| Synonyms | BDCA4, C530029I03, CD304, Neuropilin-1, NP-1, NPN-1, NRP, VEGF165R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal domain of neuropilin glycoprotein
- GTPase activator
- coagulation factor viii homology domain
- B2 box domain
- coagulation factor v homology domain
- cytoplasmic domain
- coagulation factor homology domain
- B1 box
- coagulation factor domain
- intracellular domain
- vascular endothelial growth factor receptor
- transmembrane receptor
- growth factor binding
- MAM domain, meprin/A5/mu
- coreceptor
- extracellular domain
- protein kinase binding
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- ectodomain
- protein binding
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- CUB
- transmembrane domain
- semaphorin receptor
- F5/8 type C domain
- Vegf binding domain
- FA58C
Pathways
Biological processes and signaling networks where the Nrp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- cancer
- papillomatosis
- benign neoplasia
- gastric cancer
- acute lymphoblastic leukemia
- osteosarcomagenesis
- transposition of great vessel
- rheumatoid arthritis
role in cell
- apoptosis
- activation in
- production in
- cell death
- phosphorylation in
- proliferation
- growth
- growth in
- survival
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptosomal membrane fractions
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- focal adhesions
- cytosol
- postsynaptic membrane
- neurofilaments
- growth cone
- neurites
- dendritic trees
- synapse
- early endosomes
- cytoplasmic vesicles
- membrane processes
- filopodia
- perikaryon
- axons
- dendrites
- axon terminals
- mossy fiber boutons
- axonal shafts
- sorting endosomes
- sensory axons
- mossy fibers
- motor axons
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina vasculature morphogenesis in camera-type eye
- positive chemotaxis
- trigeminal nerve structural organization
- positive regulation of filopodium assembly
- sprouting angiogenesis
- axon guidance
- cell migration involved in sprouting angiogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of angiogenesis
- axonal fasciculation
- regulation of vascular endothelial growth factor receptor signaling pathway
- regulation of Cdc42 protein signal transduction
- renal artery morphogenesis
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- cell-cell signaling
- platelet-derived growth factor receptor signaling pathway
- artery morphogenesis
- negative regulation of axon extension involved in axon guidance
- positive regulation of axon extension involved in axon guidance
- positive regulation of substrate adhesion-dependent cell spreading
- substrate-dependent cell migration, cell extension
- branchiomotor neuron axon guidance
- organ morphogenesis
- axon extension involved in axon guidance
- hepatocyte growth factor receptor signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of focal adhesion assembly
- neural crest cell migration
- positive regulation of stress fiber assembly
- semaphorin-plexin signaling pathway
- viral entry into host cell
- axonogenesis involved in innervation
- coronary artery morphogenesis
- motor axon guidance
- response to wounding
- facial nerve structural organization
- regulation of vesicle-mediated transport
- vasculogenesis
- dichotomous subdivision of terminal units involved in salivary gland branching
- negative regulation of neuron apoptotic process
- outflow tract septum morphogenesis
- neuron migration
- integrin-mediated signaling pathway
- endothelial tip cell fate specification
- patterning of blood vessels
- angiogenesis
- positive regulation of smooth muscle cell migration
- positive regulation of endothelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- commissural neuron axon guidance
- retinal ganglion cell axon guidance
- signal transduction
- vestibulocochlear nerve structural organization
- angiogenesis involved in coronary vascular morphogenesis
- cellular response to hepatocyte growth factor stimulus
- positive regulation of ERK1 and ERK2 cascade
- endothelial cell chemotaxis
- negative regulation of extrinsic apoptotic signaling pathway
- cellular response to vascular endothelial growth factor stimulus
- positive regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- receptor complex
- neurofilament
- neuron projection
- plasma membrane
- early endosome
- extracellular space
- semaphorin receptor complex
- mitochondrial membrane
- focal adhesion
- postsynaptic membrane
- cytosol
- cytoplasmic vesicle
- axon
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein kinase binding
- growth factor binding
- protein binding
- metal ion binding
- GTPase activator activity
- semaphorin receptor activity
- vascular endothelial growth factor-activated receptor activity
- heparin binding
- vascular endothelial growth factor binding
- cytokine binding