Wdr18 Gene Summary [Mouse]
Predicted to be involved in DNA-templated DNA replication and rRNA processing. Predicted to be located in dynein axonemal particle and nucleoplasm. Predicted to be part of nuclear pre-replicative complex and rixosome complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr18 |
| Official Name | WD repeat domain 18 [Source:MGI Symbol;Acc:MGI:2158400] |
| Ensembl ID | ENSMUSG00000035754 |
| Bio databases IDs | |
| Aliases | WD repeat domain 18 |
| Synonyms | 2310012I10Rik, Ipi3, R32184 1, WD repeat domain 18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Alternative WD40 repeat motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- organelle
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- pre-replicative complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding