Pelp1 Gene Summary [Mouse]
Predicted to enable SUMO binding activity and chromatin binding activity. Predicted to be involved in cellular response to estrogen stimulus; positive regulation of transcription by RNA polymerase II; and rRNA processing. Predicted to be located in euchromatin; nucleolus; and nucleoplasm. Predicted to be part of MLL1 complex. Predicted to be active in nucleus. Is expressed in cerebral cortex; hypothalamus; and midbrain. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pelp1 |
| Official Name | proline, glutamic acid and leucine rich protein 1 [Source:MGI Symbol;Acc:MGI:1922523] |
| Ensembl ID | ENSMUSG00000018921 |
| Bio databases IDs | |
| Aliases | proline, glutamic acid and leucine rich protein 1 |
| Synonyms | 4930563C04RIK, MNAR, P160, Proline and Glutamic Acid-Rich Nuclear, proline, glutamate and leucine rich protein 1, proline, glutamic acid and leucine rich protein 1, RGD1306320 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pelp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUC202 domain
- leucine rich domain
- LXXLL motif
- glutamate stretch region
- nuclear localization sequence
- rRNA processing/ribosome biogenesis
- chromatin binding
- protein binding
- glutamic acid-rich domain
- proline rich domain
- histone H1 binding domain
Pathways
Biological processes and signaling networks where the Pelp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- hyperplasia
- tumorigenesis
- mammary intraepithelial neoplasia
- cutaneous melanoma
- cutaneous melanoma cancer
- atypical hyperplasia
role in cell
- apoptosis
- activation in
- binding in
- proliferation
- expression in
- phosphorylation in
- growth
- transactivation in
- cell cycle progression
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- granular components
- nucleoplasm
- nucleoli
- nuclear speckles
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pelp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to estrogen stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- cytoplasm
- nucleolus
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- protein binding
- RNA binding
- chromatin binding