Ipo5 Gene Summary [Mouse]
Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus; cellular response to amino acid stimulus; and positive regulation of protein import into nucleus. Located in cytoplasm and nucleus. Is expressed in cerebral cortex and gonad. Orthologous to human IPO5 (importin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ipo5 |
| Official Name | importin 5 [Source:MGI Symbol;Acc:MGI:1917822] |
| Ensembl ID | ENSMUSG00000030662 |
| Bio databases IDs | |
| Aliases | importin 5 |
| Synonyms | 1110011C18Rik, 5730478E03Rik, IMB3, IMP5, Importin 5, Karyopherin beta 3, Karyopherin β 3, KPNB3, LOC685210, Pse1, RANBP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ipo5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Importin repeat
- HEAT repeat
- HEAT-like repeat
- GTPase inhibitor
- enzyme binding
- protein binding
- Importin repeat 6
- Importin-beta N-terminal domain
- HEAT repeats
- transporter
Pathways
Biological processes and signaling networks where the Ipo5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- primary cancer
- primary central nervous system lymphoma
- central nervous system cancer
- lymphoma
role in cell
- expression in
- accumulation in
- cell cycle progression
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- cell cortex
- Golgi Apparatus
- cytosol
- nuclear pores
- nucleoplasm
- nuclear envelope
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ipo5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic pattern recognition receptor signaling pathway
- cellular response to amino acid stimulus
- positive regulation of protein import into nucleus
- protein import into nucleus
- NLS-bearing substrate import into nucleus
- negative regulation of cyclin-dependent protein kinase activity
- ribosomal protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- membrane
- cytosol
- Golgi apparatus
- nucleolus
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- GTPase inhibitor activity
- small GTPase binding
- nuclear localization sequence binding