IDS Gene Summary [Human]
This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | IDS |
| Official Name | iduronate 2-sulfatase [Source:HGNC Symbol;Acc:HGNC:5389] |
| Ensembl ID | ENSG00000010404 |
| Bio databases IDs | |
| Aliases | iduronate 2-sulfatase, Hunter syndrome |
| Synonyms | AW214631, ID2S, iduronate 2-sulfatase, Iduronate-2-sulphatase, MPS2, SIDS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IDS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- iduronate-2-sulfatase
- sulfuric ester hydrolase
- calcium ion binding
- Sulfatase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mucopolysaccharidosis type II
- osteosclerosis
- glioblastoma
- glioblastoma cancer
- alopecia
- hereditary disorder
- otitis media with effusion
- mucopolysaccharidosis type I
- gait disturbance
- mucopolysaccharidosis type IIB
regulates
- glycosaminoglycan
- mineral
- chondroitin sulfate B
- heparan sulfate proteoglycan
role in cell
- formation
- proliferation
- function
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IDS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dermatan sulfate catabolic process
- heparan sulfate proteoglycan catabolic process
- glycosaminoglycan catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- iduronate-2-sulfatase activity