Ppt2 Gene Summary [Mouse]
Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be involved in macromolecule depalmitoylation. Predicted to be active in extracellular region and lysosome. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Used to study neuronal ceroid lipofuscinosis. Orthologous to human PPT2 (palmitoyl-protein thioesterase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppt2 |
| Official Name | palmitoyl-protein thioesterase 2 [Source:MGI Symbol;Acc:MGI:1860075] |
| Ensembl ID | ENSMUSG00000015474 |
| Bio databases IDs | |
| Aliases | palmitoyl-protein thioesterase 2 |
| Synonyms | 0610007M19Rik, C6orf8, G14, palmitoyl-protein thioesterase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thiolester hydrolase
- alpha/beta hydrolases
- Palmitoyl protein thioesterase
- enzyme
- hydrolase
- palmitoyl-(protein) hydrolase
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lipofuscinosis
- muscle spasm
- splenomegaly
- neurodegeneration
- experimentally-induced diabetes
- ataxia
- sarcoidosis
- COVID-19
- systemic lupus erythematosus nephritis
regulates
- acyl-coenzyme A
role in cell
- apoptosis
- number
- abnormal morphology
- cellular infiltration by
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty-acyl-CoA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- thiolester hydrolase activity