Fbxo21 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; hematopoietic stem cell differentiation; and hematopoietic stem cell homeostasis. Is expressed in nervous system and neural retina. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo21 |
| Official Name | F-box protein 21 [Source:MGI Symbol;Acc:MGI:1924223] |
| Ensembl ID | ENSMUSG00000032898 |
| Bio databases IDs | |
| Aliases | F-box protein 21 |
| Synonyms | 2810425J22Rik, F-box protein 21, FBX21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- F-box domain
- F-box domain superfamily
- Hemimethylated DNA-binding protein YccV like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- systemic autoimmune syndrome
- insomnia
- coronary artery disease
- acute myeloid leukemia
- infection by HIV-1
regulates
role in cell
- apoptosis
- differentiation
- degradation in
- polyubiquitination in
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- DNA binding
- protein binding