Fgfr4 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and heparin binding activity. Involved in several processes, including cholesterol homeostasis; phosphate ion homeostasis; and regulation of bile acid biosynthetic process. Acts upstream of or within several processes, including alveolar secondary septum development; negative regulation of fibroblast growth factor production; and positive regulation of parathyroid hormone secretion. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell-cell junction. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach cancer. Orthologous to human FGFR4 (fibroblast growth factor receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgfr4 |
| Official Name | fibroblast growth factor receptor 4 [Source:MGI Symbol;Acc:MGI:95525] |
| Ensembl ID | ENSMUSG00000005320 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor 4 |
| Synonyms | CD334, fibroblast growth factor receptor 4, JTK2, TKF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgfr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine kinase
- Protein kinase domain
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- Immunoglobulin I-set domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- fibroblast growth factor receptor
- Protein Kinases, catalytic domain
- fibroblast growth factor binding
- transmembrane domain
- immunoglobulin G-like domain
- cytosolic tail domain
- heparin binding
Pathways
Biological processes and signaling networks where the Fgfr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- CREB Signaling in Neurons
- FGF Signaling
- FXR/RXR Activation
- Hepatic Cholestasis
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- NF-κB Signaling
- PTEN Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Sperm Motility
- STAT3 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic non-small cell lung cancer
- metastatic non-squamous non-small cell lung cancer
- neoplasia
- metastasis
- bladder cancer
- Huntington disease
- metastatic colorectal adenocarcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- invasive urothelial carcinoma
role in cell
- migration
- apoptosis
- expression in
- synthesis in
- proliferation
- growth
- phosphorylation in
- activation in
- adhesion
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- transport vesicles
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgfr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- phosphate ion homeostasis
- multicellular organismal development
- positive regulation of cell proliferation
- protein autophosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- fibroblast growth factor receptor signaling pathway
- positive regulation of proteolysis
- cholesterol homeostasis
- positive regulation of catalytic activity
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- regulation of extracellular matrix disassembly
- glucose homeostasis
- positive regulation of kinase activity
- regulation of lipid metabolic process
- cell migration
- positive regulation of DNA biosynthetic process
- regulation of bile acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endosome
- cell-cell junction
- endoplasmic reticulum
- receptor complex
- Golgi apparatus
- transport vesicle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- fibroblast growth factor-activated receptor activity
- protein binding
- fibroblast growth factor binding
- heparin binding