Tmem63b Gene Summary [Mouse]
Enables calcium-activated cation channel activity; mechanosensitive monoatomic ion channel activity; and osmolarity-sensing monoatomic cation channel activity. Involved in sensory perception of sound and surfactant secretion. Located in plasma membrane. Is expressed in jaw bone; nervous system; and sensory organ. Orthologous to human TMEM63B (transmembrane protein 63B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem63b |
| Official Name | transmembrane protein 63b [Source:MGI Symbol;Acc:MGI:2387609] |
| Ensembl ID | ENSMUSG00000036026 |
| Bio databases IDs | |
| Aliases | transmembrane protein 63b |
| Synonyms | BC026370, C6orf110, RGD1305862, Tmem63b-ps1, transmembrane protein 63B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem63b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- osmosensor
- phospholipid transporter
- channel/pore class transporter
- inorganic uptake permease
- ion channel
- lipid transporter
- Calcium-dependent channel, 7TM region, putative phosphate
- phosphatidylcholine transporter
- phospholipid scramblase
- Late exocytosis, associated with Golgi transport
- sphingolipid transporter
- mechanically-gated ion channel
- Cytosolic domain of 10TM putative phosphate transporter
- cation channel
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- actin cytoskeleton
- secretory granule membrane
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem63b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- alveolar lamellar body membrane
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- mechanically-gated ion channel activity